What is the risk of taking HRT with a family history of CVD? More specifically, I have been on HRT since the age of 50. Are there any risks of continuing HRT (estrogen and progestrone, both in the transdermal application form) at my current age of 67 given I was recently assessed as having atherooscrlerosis (Calcium score of 117) and a family history of cardiovascular disease? I am no longer taking testosterone.